Question 1

What is TEMOZOLOMIDE used for?

Accepted Answer

TEMOZOLOMIDE (brand name TEMODAR) is a Other indicated for concomitantly with radiotherapy and then as maintenance treatment. 1.2 Anaplastic Astrocytoma TEMODAR is indicated for the: adjuvant treatment of adults with newly diagnosed anaplastic astrocytoma, treatment of adults with refractory anaplastic astrocytoma..

Question 2

How does TEMOZOLOMIDE work?

Accepted Answer

TEMOZOLOMIDE works through the following mechanism: 12.1 Mechanism of Action Temozolomide is not directly active but undergoes rapid nonenzymatic conversion at physiologic pH to the reactive compound 5-(3-methyltriazen-1-yl)-imidazole-4-carboxamide (MTIC). The cytotoxicity of MTIC is thought to be primarily due to DNA alkylation, mainly at the O 6 and N 7 positions of guanine, which causes DNA double strand breaks and results in programmed cell death..

Question 3

What are the most common side effects of TEMOZOLOMIDE?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for TEMOZOLOMIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is TEMOZOLOMIDE the same as TEMODAR?

Accepted Answer

TEMODAR is a brand name for TEMOZOLOMIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

TEMOZOLOMIDE

Mechanism of Action

Indications

FDA Warnings

Known Side Effects

Community Discussions

Primary sources

Compare With

Formulations