How does TIGECYCLINE work?

TIGECYCLINE works through the following mechanism: 12.1 Mechanism of Action Tigecycline is a tetracycline class antibacterial [see Microbiology ( 12.4 )] ..

What are the most common side effects of TIGECYCLINE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for TIGECYCLINE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is TIGECYCLINE the same as Tigecycline?

Tigecycline is a brand name for TIGECYCLINE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

TIGECYCLINE

Q: What is TIGECYCLINE used for?

TIGECYCLINE (brand name Tigecycline) is a Tetracycline Antibiotic indicated for including ventilator-associated pneumonia ( 1.4 ). To reduce the development of drug-resistant bacteria and maintain the effectiveness of tigecycline for injection and other antibacterial drugs, Enterococcus faecalis (vancomycin-susceptible isolates), Staphylococcus aureus (methicillin-susceptible and -resistant isolates).

Tetracycline Antibiotic

Brand names: Tigecycline

Intravenous

Mechanism of Action

12.1 Mechanism of Action Tigecycline is a tetracycline class antibacterial [see Microbiology ( 12.4 )] .

Indications

including ventilator-associated pneumonia ( 1.4 ). To reduce the development of drug-resistant bacteria and maintain the effectiveness of tigecycline for injection and other antibacterial drugs

Enterococcus faecalis (vancomycin-susceptible isolates)

Staphylococcus aureus (methicillin-susceptible and -resistant isolates)

Streptococcus agalactiae

Streptococcus anginosus grp. (includes S. anginosus

S. intermedius

FDA Warnings

5 WARNINGS AND PRECAUTIONS All-Cause Mortality: A meta-analysis of Phase 3 and 4 clinical trials demonstrated an increase in all-cause mortality in tigecycline-treated patients compared to controls with a risk difference of 0
Patients who develop abnormal liver function tests during tigecycline for injection therapy should be monitored for evidence of worsening hepatic function and evaluated for risk/benefit of continuing tigecycline therapy
4 ) Pancreatitis: including fatalities, has been reported with tigecycline for injection
In all 13 Phase 3 and 4 trials that included a comparator, death occurred in 4% (150/3,788) of patients receiving tigecycline for injection and 3% (110/3,646) of patients receiving comparator drugs

Known Side Effects

5 documented side effects by frequency

Drug Not Working

>10%

Nausea

1-10%

Vomiting

1-10%

Diarrhea

0.1-1%

Condition Worsened

0.1-1%

Community Discussions

No community discussions found for TIGECYCLINE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → TIGECYCLINE openFDA label JSON → TIGECYCLINE FAERS adverse-event reports → TIGECYCLINE ClinicalTrials.gov → completed Phase 2+ trials of TIGECYCLINE

Compare With

7 available comparisons

Formulations

Dosage Forms

Tablet

Route

Intravenous