Question 1

What is TOCILIZUMAB used for?

Accepted Answer

TOCILIZUMAB (brand name Tofidence) is a IL-6 Receptor Inhibitor indicated for non-invasive or invasive mechanical ventilation, non-invasive or invasive mechanical ventilation, or extracorporeal membrane oxygenation (ECMO)..

Question 2

How does TOCILIZUMAB work?

Accepted Answer

TOCILIZUMAB works through the following mechanism: 12.1 Mechanism of Action Tocilizumab products bind to both soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R), and have been shown to inhibit IL-6-mediated signaling through these receptors. IL-6 is a pleiotropic pro-inflammatory cytokine produced by a variety of cell types including T- and B-cells, lymphocytes, monocytes and fibroblasts. IL-6 has been shown to be involved in diverse physiological processes such as T-cell activation, induction of immunoglobulin secretion, initiation of hepatic acute phase protein synthesis, and stimulation of hematopoietic precursor cell proliferation and differentiation. IL-6 is also produced by synovial and endothelial cells leading to local production of IL-6 in joints affected by inflammatory processes such as rheumatoid arthritis..

Question 3

What are the most common side effects of TOCILIZUMAB?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for TOCILIZUMAB. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is TOCILIZUMAB the same as Tofidence?

Accepted Answer

Tofidence is a brand name for TOCILIZUMAB. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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