Question 1

What is Tofacitinib used for?

Accepted Answer

Tofacitinib (brand name Xeljanz) is a JAK Inhibitor indicated for Rheumatoid Arthritis, Psoriatic Arthritis, Ulcerative Colitis.

Question 2

How does Tofacitinib work?

Accepted Answer

Tofacitinib works through the following mechanism: Inhibits Janus kinases JAK1 and JAK3, modulating the signalling of interleukins and interferons involved in immune and inflammatory pathways..

Question 3

What are the most common side effects of Tofacitinib?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for Tofacitinib. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is Tofacitinib the same as Xeljanz?

Accepted Answer

Xeljanz is a brand name for Tofacitinib. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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