Question 1

What is TRABECTEDIN used for?

Accepted Answer

TRABECTEDIN (brand name YONDELIS) is a Other indicated for See full prescribing information.

Question 2

How does TRABECTEDIN work?

Accepted Answer

TRABECTEDIN works through the following mechanism: 12.1 Mechanism of Action Trabectedin is an alkylating drug that binds guanine residues in the minor groove of DNA, forming adducts and resulting in a bending of the DNA helix towards the major groove. Adduct formation triggers a cascade of events that can affect the subsequent activity of DNA binding proteins, including some transcription factors, and DNA repair pathways, resulting in perturbation of the cell cycle and eventual cell death..

Question 3

What are the most common side effects of TRABECTEDIN?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for TRABECTEDIN. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is TRABECTEDIN the same as YONDELIS?

Accepted Answer

YONDELIS is a brand name for TRABECTEDIN. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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