What is TRAZODONE HYDROCHLORIDE used for?

TRAZODONE HYDROCHLORIDE (brand name Trazodone Hydrochloride) is a Atypical Antidepressant indicated for See full prescribing information.

What are the most common side effects of TRAZODONE HYDROCHLORIDE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for TRAZODONE HYDROCHLORIDE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is TRAZODONE HYDROCHLORIDE the same as Trazodone Hydrochloride?

Trazodone Hydrochloride is a brand name for TRAZODONE HYDROCHLORIDE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

TRAZODONE HYDROCHLORIDE

Q: How does TRAZODONE HYDROCHLORIDE work?

TRAZODONE HYDROCHLORIDE works through the following mechanism: 12.1 Mechanism of Action The mechanism of trazodone's antidepressant action is not fully understood, but is thought to be related to its enhancement of serotonergic activity in the CNS. Trazodone is both a selective serotonin reuptake inhibitor (SSRI) and a 5HT2 receptor antagonist and the net result of this action on serotonergic transmission and its role in trazodone's antidepressant effect is unknown..

Atypical Antidepressant

Brand names: Trazodone Hydrochloride

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of trazodone's antidepressant action is not fully understood, but is thought to be related to its enhancement of serotonergic activity in the CNS. Trazodone is both a selective serotonin reuptake inhibitor (SSRI) and a 5HT2 receptor antagonist and the net result of this action on serotonergic transmission and its role in trazodone's antidepressant effect is unknown.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS None ( 4 ). Concomitant use of monoamine oxidase inhibitors (MAOIs)
• or use within 14 days of stopping MAOIs ( 4 ). Trazodone hydrochloride tablets are contraindicated in: Patients taking
• or within 14 days of stopping
• monoamine oxidase inhibitors (MAOIs)
• including MAOIs such as linezolid or intravenous methylene blue

FDA Warnings

5 WARNINGS AND PRECAUTIONS Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e
Avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval ( 5
3 ) Orthostatic Hypotension and Syncope: Warn patients of risk and symptoms of hypotension ( 5
Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5

Known Side Effects

13 documented side effects by frequency

Drug Not Working

>10%

Fatigue

1-10%

Nausea

1-10%

Headache

1-10%

Diarrhea

1-10%

Vomiting

1-10%

Insomnia

1-10%

Depression

1-10%

Shortness of Breath

1-10%

Dizziness

1-10%

Falls

1-10%

Weakness

0.1-1%

Anxiety

0.1-1%

Community Discussions

No community discussions found for TRAZODONE HYDROCHLORIDE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → TRAZODONE HYDROCHLORIDE openFDA label JSON → TRAZODONE HYDROCHLORIDE FAERS adverse-event reports → TRAZODONE HYDROCHLORIDE ClinicalTrials.gov → completed Phase 2+ trials of TRAZODONE HYDROCHLORIDE

Compare With

7 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral