What is VALBENAZINE used for?

VALBENAZINE (brand name INGREZZA) is a Other indicated for See full prescribing information.

What are the most common side effects of VALBENAZINE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for VALBENAZINE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is VALBENAZINE the same as INGREZZA?

INGREZZA is a brand name for VALBENAZINE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

VALBENAZINE

Q: How does VALBENAZINE work?

VALBENAZINE works through the following mechanism: 12.1 Mechanism of Action The mechanism of action of valbenazine for the treatment of tardive dyskinesia and chorea in patients with Huntington’s disease is unclear, but is thought to be mediated through the reversible inhibition of vesicular monoamine transporter 2 (VMAT2), a transporter that regulates monoamine uptake from the cytoplasm to the synaptic vesicle for storage and release..

Other

Brand names: INGREZZA, INGREZZA Sprinkle

Oral

Mechanism of Action

12.1 Mechanism of Action The mechanism of action of valbenazine for the treatment of tardive dyskinesia and chorea in patients with Huntington’s disease is unclear, but is thought to be mediated through the reversible inhibition of vesicular monoamine transporter 2 (VMAT2), a transporter that regulates monoamine uptake from the cytoplasm to the synaptic vesicle for storage and release.

Indications

See full prescribing information

Contraindications

• 4 CONTRAINDICATIONS INGREZZA and INGREZZA SPRINKLE are contraindicated in patients with a history of hypersensitivity to valbenazine or any components of INGREZZA or INGREZZA SPRINKLE. Rash
• urticaria
• and reactions consistent with angioedema (e.g.
• swelling of the face
• lips

FDA Warnings

5 WARNINGS AND PRECAUTIONS Depression and suicidal ideation and behavior in patients with Huntington’s disease
1 Depression and Suicidal Ideation and Behavior in Patients with Huntington’s Disease Patients with Huntington’s disease are at increased risk for depression, and suicidal ideation or behaviors
VMAT2 inhibitors, including INGREZZA and INGREZZA SPRINKLE, can increase the risk for suicidal ideation and behaviors in patients with Huntington’s disease
Patients with significant risk for suicidal behavior or with unstable psychiatric symptoms were excluded from this trial

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Drowsiness

>10%

Fatigue

1-10%

Tremor

1-10%

Falls

1-10%

Dizziness

1-10%

Anxiety

0.1-1%

Nausea

0.1-1%

Community Discussions

No community discussions found for VALBENAZINE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → VALBENAZINE openFDA label JSON → VALBENAZINE FAERS adverse-event reports → VALBENAZINE ClinicalTrials.gov → completed Phase 2+ trials of VALBENAZINE

Compare With

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Formulations

Dosage Forms

Tablet

Route

Oral