How does VANCOMYCIN work?

VANCOMYCIN works through the following mechanism: 12.1 Mechanism of Action Vancomycin is an antibacterial drug [see Microbiology (12.4) ] ..

What are the most common side effects of VANCOMYCIN?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for VANCOMYCIN. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is VANCOMYCIN the same as Vancomycin?

Vancomycin is a brand name for VANCOMYCIN. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

VANCOMYCIN

Q: What is VANCOMYCIN used for?

VANCOMYCIN (brand name Vancomycin) is a Glycopeptide / Oxazolidinone Antibiotic indicated for or those patients who cannot receive or who have failed to respond to other drugs, Enterococcus species and Corynebacterium species. For enterococcal endocarditis, use Vancomycin Injection in combination with an aminoglycoside. Methicillin-susceptible staphylococci in penicillin-allergic patients.

Glycopeptide / Oxazolidinone Antibiotic

Brand names: Vancomycin

Intravenous

Mechanism of Action

12.1 Mechanism of Action Vancomycin is an antibacterial drug [see Microbiology (12.4) ] .

Indications

or those patients who cannot receive or who have failed to respond to other drugs

Enterococcus species and Corynebacterium species. For enterococcal endocarditis

use Vancomycin Injection in combination with an aminoglycoside. Methicillin-susceptible staphylococci in penicillin-allergic patients

or those patients who cannot receive or who have failed to respond to other drugs

Contraindications

• 4 CONTRAINDICATIONS Vancomycin Injection is contraindicated in patients with known hypersensitivity to vancomycin. Hypersensitivity to vancomycin ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS Infusion Reactions : Hypotension, including shock and cardiac arrest, wheezing, dyspnea, urticaria, muscular and chest pain and "red man syndrome" which manifests as pruritus and erythema that involves the face, neck and upper torso may occur with rapid intravenous administration
To reduce the risk of infusion reactions, administer Vancomycin Injection over a period of 60 minutes or greater and also prior to intravenous anesthetic agents
8 ) Phlebitis : To reduce the risk of local irritation and phlebitis administer Vancomycin Injection by a secure intravenous route of administration
9 ) Development of Drug-Resistant Bacteria : Prescribing Vancomycin Injection in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to the patient and increases the risk of the development of drug resistant bacteria

Known Side Effects

8 documented side effects by frequency

Drug Not Working

>10%

Fever

1-10%

Diarrhea

1-10%

Rash

0.1-1%

Low Blood Pressure

0.1-1%

Condition Worsened

0.1-1%

Shortness of Breath

0.1-1%

Nausea

0.1-1%

Community Discussions

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Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → VANCOMYCIN openFDA label JSON → VANCOMYCIN FAERS adverse-event reports → VANCOMYCIN ClinicalTrials.gov → completed Phase 2+ trials of VANCOMYCIN

Compare With

3 available comparisons

Formulations

Dosage Forms

Tablet

Route

Intravenous