Question 1

What is VIGABATRIN used for?

Accepted Answer

VIGABATRIN (brand name VIGADRONE) is a Anticonvulsant indicated for See full prescribing information.

Question 2

How does VIGABATRIN work?

Accepted Answer

VIGABATRIN works through the following mechanism: 12.1 Mechanism of Action The precise mechanism of vigabatrin's anti-seizure effect is unknown, but it is believed to be the result of its action as an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T), the enzyme responsible for the metabolism of the inhibitory neurotransmitter GABA. This action results in increased levels of GABA in the central nervous system. No direct correlation between plasma concentration and efficacy has been established. The duration of drug effect is presumed to be dependent on the rate of enzyme re-synthesis rather than on the rate of elimination of the drug from the systemic circulation..

Question 3

What are the most common side effects of VIGABATRIN?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for VIGABATRIN. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is VIGABATRIN the same as VIGADRONE?

Accepted Answer

VIGADRONE is a brand name for VIGABATRIN. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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