How does VORICONAZOLE work?

VORICONAZOLE works through the following mechanism: 12.1 Mechanism of Action Voriconazole is an antifungal drug [see Microbiology (12.4) ]..

What are the most common side effects of VORICONAZOLE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for VORICONAZOLE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is VORICONAZOLE the same as VFEND?

VFEND is a brand name for VORICONAZOLE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

VORICONAZOLE

Q: What is VORICONAZOLE used for?

VORICONAZOLE (brand name VFEND) is a Antifungal indicated for in patients intolerant of, or refractory to, other therapy ( 1.4 ) 1.1 Invasive Aspergillosis VFEND is indicated in adults and pediatric patients (2 years of age and older) for the treatment of invasive aspergillosis (IA). In clinical trials.

Antifungal

Brand names: VFEND

Intravenous

Mechanism of Action

12.1 Mechanism of Action Voriconazole is an antifungal drug [see Microbiology (12.4) ].

Indications

in patients intolerant of

or refractory to

other therapy ( 1.4 ) 1.1 Invasive Aspergillosis VFEND is indicated in adults and pediatric patients (2 years of age and older) for the treatment of invasive aspergillosis (IA). In clinical trials

kidney

bladder wall

and wounds [see Clinical Studies (14.2

Contraindications

• 4 CONTRAINDICATIONS • VFEND is contraindicated in patients with known hypersensitivity to voriconazole or its excipients [see Warnings and Precautions (5.5) and Adverse Reactions (6.1
• and for which elevated plasma concentrations are associated with serious and/or life‑threatening reactions [see Drug Interactions (7) ]: • Eplerenone • Ergot alkaloids (e.g.
• ergotamine
• CYP2C9
• and for which elevated plasma concentrations are associated with serious and/or life-threatening reactions ( 4

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Hepatic Toxicity : Serious hepatic reactions reported
5 ) • Photosensitivity : Avoid sunlight due to risk of photosensitivity ( 5
1 Hepatic Toxicity In clinical trials, there have been uncommon cases of serious hepatic reactions during treatment with VFEND (including clinical hepatitis, cholestasis and fulminant hepatic failure, including fatalities)
Instances of hepatic reactions were noted to occur primarily in patients with serious underlying medical conditions (predominantly hematological malignancy)

Known Side Effects

6 documented side effects by frequency

Drug Not Working

>10%

Fever

1-10%

Condition Worsened

1-10%

Diarrhea

0.1-1%

Nausea

0.1-1%

Shortness of Breath

0.1-1%

Community Discussions

No community discussions found for VORICONAZOLE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → VORICONAZOLE openFDA label JSON → VORICONAZOLE FAERS adverse-event reports → VORICONAZOLE ClinicalTrials.gov → completed Phase 2+ trials of VORICONAZOLE

Compare With

14 available comparisons

Formulations

Dosage Forms

Tablet

Route

Intravenous