Question 1

What is VOXELOTOR used for?

Accepted Answer

VOXELOTOR (brand name OXBRYTA) is a Other indicated for See full prescribing information.

Question 2

How does VOXELOTOR work?

Accepted Answer

VOXELOTOR works through the following mechanism: 12.1 Mechanism of Action Voxelotor is a hemoglobin S (HbS) polymerization inhibitor that binds to HbS with a 1:1 stoichiometry and exhibits preferential partitioning to red blood cells (RBCs). By increasing the affinity of Hb for oxygen, voxelotor demonstrates dose-dependent inhibition of HbS polymerization. Nonclinical studies suggest that voxelotor may inhibit RBC sickling, improve RBC deformability, and reduce whole blood viscosity..

Question 3

What are the most common side effects of VOXELOTOR?

Accepted Answer

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for VOXELOTOR. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Question 4

Is VOXELOTOR the same as OXBRYTA?

Accepted Answer

OXBRYTA is a brand name for VOXELOTOR. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

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