How does ZIDOVUDINE work?

ZIDOVUDINE works through the following mechanism: 12.1 Mechanism of Action Zidovudine is an antiretroviral agent [see Microbiology ( 12.4 )]..

What are the most common side effects of ZIDOVUDINE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for ZIDOVUDINE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is ZIDOVUDINE the same as Zidovudine?

Zidovudine is a brand name for ZIDOVUDINE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

ZIDOVUDINE

Q: What is ZIDOVUDINE used for?

ZIDOVUDINE (brand name Zidovudine) is a Other indicated for a nucleoside reverse transcriptase inhibitor, women in the first trimester of pregnancy who do not require immediate initiation of antiretroviral therapy for their own health may consider delaying use, this indication is based on use after 14 weeks' gestation..

Other

Brand names: Zidovudine

Oral

Mechanism of Action

12.1 Mechanism of Action Zidovudine is an antiretroviral agent [see Microbiology ( 12.4 )].

Indications

a nucleoside reverse transcriptase inhibitor

women in the first trimester of pregnancy who do not require immediate initiation of antiretroviral therapy for their own health may consider delaying use

this indication is based on use after 14 weeks' gestation.

Contraindications

• 4 CONTRAINDICATIONS Zidovudine tablets are contraindicated in patients who have had a potentially life-threatening hypersensitivity reaction (e.g.
• anaphylaxis
• Stevens-Johnson syndrome) to any of the components of the formulations. Hypersensitivity to zidovudine or any of the components (e.g.
• anaphylaxis
• Stevens-Johnson syndrome). ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS • See boxed warning for information about the following: hematologic toxicity, myopathy, and lactic acidosis and severe hepatomegaly ( 5
5 ) • Hepatic decompensation, (some fatal), has occurred in HIV-1/HCV co-infected patients receiving combination antiretroviral therapy and interferon alfa with/without ribavirin
4 Lactic Acidosis and Severe Hepatomegaly with Steatosis Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues, including zidovudine
Female sex and obesity may be risk factors for the development of lactic acidosis and severe hepatomegaly with steatosis in patients treated with antiretroviral nucleoside analogues

Known Side Effects

2 documented side effects by frequency

Anxiety

1-10%

Fever

0.1-1%

Community Discussions

No community discussions found for ZIDOVUDINE yet.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → ZIDOVUDINE openFDA label JSON → ZIDOVUDINE FAERS adverse-event reports → ZIDOVUDINE ClinicalTrials.gov → completed Phase 2+ trials of ZIDOVUDINE

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Formulations

Dosage Forms

Tablet

Route

Oral