Compare Lisinopril (Zestril) and VALSARTAN (Valsartan) — clinical data, side effects, and patient experiences.
Zestril, Prinivil · ACE Inhibitor
How it works
Inhibits angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, leading to decreased blood pressure and reduced al...
Approved for
Valsartan, Diovan · ARB
How it works
12.1 Mechanism of Action Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pr...
Approved for
Estimated frequency (%) based on clinical trial data
Based on 20 Reddit discussions
Lisinopril
67%
positive
6 threads
VALSARTAN
21%
positive
14 threads
% of discussions mentioning each side effect
6 Reddit threads analysed for Lisinopril
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
46 upvotes
Most discussed side effects in community
I wanted to share my experience in case it helps someone who might be in the same confusing situation I was in. I’m a **46 year old male,** fairly active, healthy weight, and generally careful with my lifestyle. About a year and a half ago, I started paying closer attention to my blood pressure, whi
Just wanted to share my story of getting my BP under control as motivation for all of us who struggle with it. I am 46 yo, fit and athletic individual (155lbs, distance runner, scuba diver) who had a reasonably good diet and mild alcohol use. During a regular health checkup, my BP was very high and
I've been dealing with high blood pressure for 6-7 years now, back in 2020 it was as high as 160/110, and no meds helped me until I finally went on 40 mg of Lisinopril and 12.5 mg of HCTZ. Last year I got into a minor car accident and they incidentally found a small tumor on my left adrenal gland. T
I have had stage two hypertension for almost a decade now, at age 37. It's mostly my regular body so it hasn't been possible to reach normal levels without meds. I was on 5 mg Lisinopril and 5 mg of amlodopine for a while, but after losing weight and exercising I was able to go off amlodopine. But t
I went to the doctor today to be seen for retina problems arising from high blood pressure..but, when they took my blood pressure (I have been on beetroot for about a month now), they said my blood pressure was 100/68? I could not believe it, I thought they were going to give me lisinopril or someth
Losing hope For the sake of brevity, I’ll leave out a long story that goes with this. 35 male other wise healthy Treatment resistant hypertension with PVCs and tachycardia since 18 years of age. On 4-5 BP meds nothing really works. Renal artery scan - nothing Aldosterone abnormalities - none Adrena
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
14 Reddit threads analysed for VALSARTAN
Overall Sentiment
Mixed
Comparison Threads
0
Avg Post Score
9 upvotes
Most discussed side effects in community
Saw my Dr. on Jan 5 and reviewed my BP trends since October. He agreed to let me stop the drug. I’ll continue to track one because I dropped a load on a smart BP monitor, also to see if I do need to restart down the line. This is really exciting for me, I got more active over the course of 2025 an
I’ve been on a beta blocker since I was 25 (I’m 42 now) and my doc added valsartan about 3 years ago during the pandemic (during which time I was under a lot of stress and drank more alcohol). During the worst of that time I probably drank 10-15 drinks a week. Never been overweight, though, and regu
Started going to a new cardiologist for HBP three years ago. Initially he put me on Valsartan, but switched me to Lorsartan (you know, because of the whole rocket fuel thing). Then put me on a mild dose of HCTZ. Then about three years ago, he put me on carvidelol (the beta blocker). Long story short
Hi all, Writing for support. About 2 months ago I went to an unrelated GP appointment and a routine BP reading was taken. My BP was 180/120, several more were taken and it was still the same. I’m 27 female, 60kg, exercise regularly (mostly weights not cardio). I was quickly seen by a cardiologist an
A while ago I was put on Amlodipin and ended up in the ER after all bowel movements stopped.. according to my Dr, that was a very rare side effect he had personally never heard of. A month ago I was at the Dr office again after a few months without meds and my BP was 160/100. I was put on Valsartan
A few years ago, I went for a checkup during a time of high anxiety, I was even having panic attacks randomly and having insomnia. Obviously the readings were high 145/95 and was prescribed with valsartan. After that I got treatment for anxiety, and feel a lot better but now I am affraid to leave
Hi everybody I have tried all these three Losartan, Valsartan, Amlodipine. They all make me feel dizzy, stressed out, worried and depressed. Have someone had the same issues? Don’t know really what to do. I felt my health has really decreased since started on BP medicines. Thanks to all.God bless e
Quick background on me. I lost my wife in November and had an Afib incident in February. I knew my BP wasn’t ideal but wasn’t forced to do anything about it until after the Afib incident. Since then I was put on Chlorthaladone and Valsartan. I noticed some mild muscle fatigue and it’s been progress
Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.
Lisinopril is a ACE Inhibitor, while VALSARTAN belongs to the ARB class. This means they work through different pharmacological mechanisms, which may influence both efficacy and side effect profiles.
Lisinopril carries 2 FDA warnings. VALSARTAN carries 4 FDA warnings. Patients should discuss all warnings and contraindications with their healthcare provider before starting or switching medications..
This comparison is for informational purposes only. Always consult a qualified healthcare professional before making medication decisions.
Every figure on this comparison links back to its primary source. See data sources and methodology for the full provenance trail.