What are the most common side effects of AMLODIPINE?

Reported side effects vary by individual. The side-effects section on this page lists the events most frequently reported to FDA FAERS for AMLODIPINE. FAERS is voluntary reporting, so it reflects what was reported, not absolute incidence.

Is AMLODIPINE the same as amlodipine?

amlodipine is a brand name for AMLODIPINE. They share the same active ingredient and FDA-approved indications. Biosimilars and authorised generics may differ in inactive ingredients such as buffers or preservatives.

AMLODIPINE

Q: What is AMLODIPINE used for?

AMLODIPINE (brand name amlodipine) is a ARB indicated for 1 INDICATIONS & USAGE Amlodipine, valsartan and hydrochlorothiazide tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events.

Q: How does AMLODIPINE work?

AMLODIPINE works through the following mechanism: 12.1 Mechanism of Action The active ingredients of amlodipine, valsartan and hydrochlorothiazide tablets target 3 separate mechanisms involved in blood pressure regulation. Specifically, amlodipine blocks the contractile effects of calcium on cardiac and vascular smooth muscle cells; valsartan blocks the vasoconstriction and sodium retaining effects of angiotensin II on cardiac, vascular smooth muscle, adrenal and renal cells; and hydrochlorothiazide directly promotes the excretion of sodium and chloride in the kidney leading to reductions in intravascular volume. A more detailed description of the mechanism of action of each individual component follows. Amlodipine Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular.

ARB

Brand names: amlodipine, Norvasc, Exforge HCT

Oral

Mechanism of Action

12.1 Mechanism of Action The active ingredients of amlodipine, valsartan and hydrochlorothiazide tablets target 3 separate mechanisms involved in blood pressure regulation. Specifically, amlodipine blocks the contractile effects of calcium on cardiac and vascular smooth muscle cells; valsartan blocks the vasoconstriction and sodium retaining effects of angiotensin II on cardiac, vascular smooth muscle, adrenal and renal cells; and hydrochlorothiazide directly promotes the excretion of sodium and chloride in the kidney leading to reductions in intravascular volume. A more detailed description of the mechanism of action of each individual component follows. Amlodipine Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular

Indications

1 INDICATIONS & USAGE Amlodipine

valsartan and hydrochlorothiazide tablets are indicated for the treatment of hypertension

to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events

primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes

including amlodipine

hydrochlorothiazide

Contraindications

• 4 CONTRAINDICATIONS Do not use in patients with anuria
• hypersensitivity to other sulfonamide-derived drugs
• or hypersensitivity to any component of this product. Do not coadminister aliskiren with amlodipine
• valsartan and hydrochlorothiazide tablets in patients with diabetes ( 4 )

FDA Warnings

5 WARNINGS AND PRECAUTIONS • Hypotension: Correct volume depletion prior to initiation ( 5
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death
Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death
, patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on amlodipine, valsartan and hydrochlorothiazide tablets

Known Side Effects

12 documented side effects by frequency

Fatigue

1-10%

Diarrhea

1-10%

Nausea

1-10%

Shortness of Breath

1-10%

Drug Not Working

1-10%

Dizziness

1-10%

Headache

1-10%

Weakness

1-10%

Falls

1-10%

Vomiting

1-10%

High Blood Pressure

1-10%

General Unwellness

1-10%

Community Discussions

5 Reddit threads analysed for AMLODIPINE

Overall Sentiment

Mixed

Comparison Threads

Avg Post Score

53 upvotes

Most discussed side effects in community

Anxiety (2)

Dizziness (2)

Brain Fog (1)

Tremor (1)

Weight Loss (1)

Headache (1)

Patient Experiences (r/pharmacy, r/AskDocs & more)

Amlodipine …. This medicine is horrendous. Anyone else?

35 male with high BP my entire life Been on it for 1 year and 5 months. Started at 5 mg for like 3 or 6 months then went to 10 mg. Seems I have a barrage of symptoms I’ve never had before in my life for the last 6 months. Extreme daytime sleepiness***** The chills like 15 times a day ***** Swollen

r/hypertension1003143y ago

Today is exactly 1 year since measuring blood pressure changed my life.

I was hungover, ate prosciutto, hands were shaking like crazy. I thought I'd measure it just for the fun of it. It wasn't fun when the numbers never in 10 measurement went lower than 210/120, going to the ER made things worse. It was all in my head. But we fixed it. Hell started. 2 months passed and

r/hypertension73224mo ago

Anxiety

Brain Fog

Tremor

I stopped taking BP meds after losing 45 lbs!

Just wanted to brag on myself a bit here. Since February I've been taking GLP-1 and I'm down 45lbs (247-202). My GW is 170 so I still have a ways to go but recently I've been having weird dizzy spells when bending down and standing back up. There are a lot of potential causes of course, but my BP ha

r/hypertension691710mo ago

Dizziness

Weight Loss

Something is wrong with me

So I do not know exactly where to start, this whole process seems to me like an XXL episode of Dr. House with no end. So it all started with a head pressure about 3 weeks ago, I dont know exactly how to describe this I would not say that its a headache, much more like air is building up in my bra

r/HeartDisease12114y ago

Headache

Dizziness

Anxiety

CAC 8000+

Just found out that my father’s CAC score is 8000+. Cholesterol is 169. The score shocked me and I don’t know what to do. He’s scheduled for angiography in 1 week. I am concerned whether something could happen in 1 week… I live in another country and can’t get to him (no visa). He was told to take a

r/Cholesterol102711mo ago

Community discussions are sourced from public Reddit threads. Content reflects individual opinions and is not medical advice.

Primary sources

Every figure on this page links back to its primary source. See data sources for full provenance.

DailyMed FDA label search → AMLODIPINE openFDA label JSON → AMLODIPINE FAERS adverse-event reports → AMLODIPINE ClinicalTrials.gov → completed Phase 2+ trials of AMLODIPINE

Compare With

20 available comparisons

Formulations

Dosage Forms

Tablet

Route

Oral